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Endogenous Droops [modify] Small lymphocyte stimulating (Mls) exotoxins were originally discovered in the thymic stromal cells of mice. These toxic substances are encoded by SAg genes that were included into the mouse genome from the mouse mammary tumour infection (MMTV). The existence of these genes in the mouse genome permits the mouse to express the antigen in the thymus as a means of adversely picking for lymphocytes with a variable Beta region that is vulnerable to stimulation by the viral SAg.

Similar endogenous SAg-dependent selection has yet to be recognized in the human genome, however endogenous SAgs have been found and are thought of playing an integral function in viral infection. Infection by the Epstein, Barr infection, for instance, is known to cause production of a SAg in contaminated cells, yet no gene for the contaminant has been discovered on the genome of the infection.

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Comparable results have been discovered with rabies, cytomegalovirus, and HIV. Recommendations [modify] Llewelyn M, Cohen J (March 2002). "Superantigens: microbial representatives that corrupt resistance". Lancet Infect Dis. 2 (3 ): 15662. doi:10. 1016/S1473 -3099( 02 )00222-0.  neobladder surgery . Li H., Llera A., Malchiodi E.L., Mariuzza R.A. The structural basis of T cell activation by superantigens.

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J. Exp. Medication. 182 (5 ): 15737. doi:10. 1084/jem. 182.5. 1573. PMC. PMID 7595227. Papageorgiou A/c, Tranter HS, Acharya KR (March 1998). "Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1. 5 A resolution: implications for superantigen acknowledgment by MHC class II particles and T-cell receptors". J. Mol. Biol.

Staphylococcal and Streptococcal Superantigen Exotoxins - Clinical  Microbiology Reviews

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